RAS mutations occur in approximately 20% of all cancers and given their clonality, key role as driver mutation, association with poor prognosis and undruggability, they represent attractive targets for immunotherapy.We have identified immunogenic peptides derived from codon 12 mutant RAS (G12A, G12C, G12D, G12R, G12S and G12V), which bind to Pillow

The electrical discharge machining could be used sometimes to improve the roughness of the machined surfaces.The values of the surface roughness parameters are affected by the characteristics of the electrical NIACIN NO-FLUSH discharges developed between the closest asperities existing on the active surface of the tool electrode and on the workpiec

The transgender experience predicts that the gender affirming pathway is undertaken.The gender affirmation process is not mandatory, and the process is not the same for all people.Affirmation of gender is a social determinant of transgender and gender diverse (TGD) health, but which also has a multidimensional structure: social, legal, psychologica

This study was conducted to examine the communication skills and self-efficacy levels of individuals working as coaches.The population of this study, which was conducted using a descriptive research model, consisted of coaches working actively in Turkey, while the sample group consisted of a total of 697 coaches, 203 women and 494 men, on a volunta

Aiming at the existing relevant problems in cost management for the projects of petrochemical enterprises, this paper includes a large quantity of practical data and summarizes the indicators 3 Piece Twin Panel Bed which influence the cost of projects of petrochemical enterprises into 14 indicators including investment scale, integrated operation,